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Sensorineural Hearing Loss in Patients on Treatment For Drug- Resistant Tuberculosis: A Case Study – World Congress on Endoscopic Ear Surgery

Sensorineural Hearing Loss in Patients on Treatment For Drug- Resistant Tuberculosis: A Case Study

By June 8, 2019

Gaffar, Masyita1,2; Toding, Ribka2; Aryani, Jamaluddin3
1 Department of Otorhinolaryngology-Head and Neck Surgery, Hasanuddin University, Makassar, Indonesia;
2 Department of Otorhinolaryngology-Head and Neck Surgery, Labuang Baji Hospital, Makassar, Indonesia;
3 Division of Pulmonology,  Labuang Baji Hospital, Makassar, Indonesia.

Introduction:
Multi-drug resistant tuberculosis (MDR-TB) is the biggest problem against the prevention and eradication of tuberculosis globally. The treatment of drug-resistant tuberculosis with a long-term administration of second line drugs comprising injectable aminoglycosides kanamycin with the resultant increased incidence of significant adverse effects is still being commonly used in developing countries.

Methods:
We describe seven patients with MDR-TB who were under medication for the same i.e kanamycin injection along few more antibacterial agents and antituberculosis agents.
Pure tone audiometry performed before MDR-TB treatment and after 3 months of therapy for all patients.

Results:
The result of audiological evaluation after three months therapy of MDR-TB, out of the seven patients, four patients considered for the study had  sensorineural hearing loss, where 4,6 and 8 kHZ were more affected compared to low frequencies.

Conclusion:
Aminoglycosides in MDR-TB patients may cause hearing loss involving higher frequencies, thus the need for regular audiologic evaluation and  hearing monitoring in patients with MDR-TB during the treatment