Clinical Outcome of Tympanoplasty with Porcine Small Intestine Mucosa-our experience in Taiwan

By June 7, 2019

Yang, Hsin-Ting1; Chen, Chin-Kuo1
1 Department of Otolaryngology- Head and Neck Surgery and Communication Enhancement Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

Tympanic membrane perforation is a common disease, and often leads to hearing loss, ear leakage, earache and cholesteatoma. Tympanoplasty or myringoplasty often use autologous and allografts to repair the perforation. The biodesign – Porcine small intestine submucosa, is widely used in various surgical procedures, gradually applied to ear surgery. Our study presented the results of transcanal endoscopic tympanoplasty with biosynthetic materials to repair the eardrum perforation.

Retrospective cases series study in a tertiary medical center. All patients accept Transcanal endoscopic tympanoplasty to repair the eardrum perforations. Pre-operative and post-operative pure tone audiometric test was used to evaluate the clinical outcome of hearing in patients with simple eardrum perforation.

All patients underwent endoscopic tympanoplasty with biodesign. The perforation of the eardrum is central (100%) and all with larger perforation sizes. Audiometric reports showed significant improvement in levels at all frequencies (under paired Wilcoxon sign rank, P <0.05). There were no postoperative complications, such as vertigo, hearing loss and tinnitus reported.

In this study, all patients using endoscopic tympanoplasty with biodesign implantation are no wounds cutting and sutured. The overall success rate of tympanic membrane perforation closure was 100%. Postoperative hearing results were significantly improved and better than pre-operative hearing acuities. There were no limits to perforation sizes. The biodesign as a graft substitutes the autologous tissue has benefit of postoperative wound healing and cosmetic results.